Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi002-A) from a patient with spinocerebellar ataxia type 3

Liting Wei; Jwei Zhang; Dingbang Chen; Li Feng; Chao Wu; Rui Wang; Xunhua Li

Stem Cell Research (Aug 2020)

Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi002-A) from a patient with spinocerebellar ataxia type 3

Liting Wei,
Jwei Zhang,
Dingbang Chen,
Li Feng,
Chao Wu,
Rui Wang,
Xunhua Li

Affiliations

Liting Wei: Department of Neurology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan 467500, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 510052, China
Jwei Zhang: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 510052, China; Corresponding authors at: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Dingbang Chen: Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Li Feng: Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Chao Wu: Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Rui Wang: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangzhou 510530, China
Xunhua Li: Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Corresponding authors at: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Journal volume & issue: Vol. 47
p. 101898

Abstract

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Using a non-integrative reprogramming method, a human iPSC Line, ZZUNEUi002-A, was generated from a 22-year-old male patient with spinocerebellar ataxia type 3 /Machado-Joseph disease (SCA3/MJD). This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype. The iPSC line could be used as a tool for mechanism researching and drug screening.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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