A case of human rabies with a long incubation period in Wuhan
Meng Shengli,
Li Qian,
Sun Yan,
Wu Wenjuan,
Wu Jie,
Shi Jinrong,
Wang Zejun,
Li Xingguo
Affiliations
Meng Shengli
National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co. Ltd., Wuhan, 430207, China
Li Qian
National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co. Ltd., Wuhan, 430207, China
Sun Yan
Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan, 430074, China
Wu Wenjuan
Wuhan Golden Yingtan Hospital, Wuhan, 430022, China
Wu Jie
National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co. Ltd., Wuhan, 430207, China
Shi Jinrong
National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co. Ltd., Wuhan, 430207, China
Wang Zejun
National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co. Ltd., Wuhan, 430207, China
Li Xingguo
National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co. Ltd., Wuhan, 430207, China; Corresponding author.
Rabies remains endemic in China and continues to pose a major threat to public health with a nearly 100 % case fatality rate in humans. We confirmed a case of human rabies in Wuhan, in May 2018. The patient had got a dog bite wound 3 years before symptoms of confusion, hydrophobia, and photophobia onset. On May 14, our laboratory confirmed that the patient was infected with a rabies virus that circulates in dogs in China and died on May 24, two weeks later after admission. Complete glycoprotein gene sequences determined for this isolate indicated the source of a RABV infection was dog-related RABV variants.
