Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV‑1 Protease

• Andres Wong-Sam,
• Yuan-Fang Wang,
• Ying Zhang,
• Arun K. Ghosh,
• Robert W. Harrison,
• Irene T. Weber

Affiliations

Andres Wong-Sam

†Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia, United States

Yuan-Fang Wang

†Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia, United States

Ying Zhang

†Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia, United States

Arun K. Ghosh

Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana, United States

Robert W. Harrison

†Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia, United States

Irene T. Weber

†Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia, United States