Mechanisms and clinical translation of high altitudepulmonary edema: current status and future prospects
Gao Wenxiang,
Wu Gang,
Xu Licong,
Gao Yuqi
Affiliations
Gao Wenxiang
College of High Altitude Military Medicine, Institute of Medicine and Hygienic Equipment for High Altitude Region,Army Medical University, Chongqing 400038, China;Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China，Chongqing 400038, China；Key Laboratory of High Altitude Medicine, PLA, Chongqing 400038, China
Wu Gang
College of High Altitude Military Medicine, Institute of Medicine and Hygienic Equipment for High Altitude Region,Army Medical University, Chongqing 400038, China;Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China，Chongqing 400038, China；Key Laboratory of High Altitude Medicine, PLA, Chongqing 400038, China
Xu Licong
Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China，Chongqing 400038, China；Key Laboratory of High Altitude Medicine, PLA, Chongqing 400038, China；Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China
Gao Yuqi
College of High Altitude Military Medicine, Institute of Medicine and Hygienic Equipment for High Altitude Region,Army Medical University, Chongqing 400038, China;Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China，Chongqing 400038, China；Key Laboratory of High Altitude Medicine, PLA, Chongqing 400038, China
High altitude pulmonary edema (HAPE) is a form of life-threatening high altitude idiopathy.This non-cardiogenic pulmonary edema is a serious illness with high risk of morbidity. The mechanisms of HAPEmostly proposed so far in literature include exaggerated hypoxic pulmonary vasoconstriction (HPV) and excessively increased capillary pressure, pulmonary capillary leak, disturbed alveolar fluid clearance, and liquid retention and body fluid imbalance. In this review, we described the advances in HAPE mechanisms and in the clinicaltranslation of therapeutics targeting the central links of HAPE pathophysiology. We also provided views on the fu‐ture prospects for the pharmacological management of HAPE, which should inspire high altitude medical research‐ers to find new measures to prevent and treat HAPE.
