New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton
Gabriel Mencia,
Tania Lozano-Cruz,
Mercedes Valiente,
Javier de la Mata,
Jesús Cano,
Rafael Gómez
Affiliations
Gabriel Mencia
Departamento de Química Orgánica y Química Inorgánica, IQAR, Universidad de Alcalá, Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
Tania Lozano-Cruz
Departamento de Química Orgánica y Química Inorgánica, IQAR, Universidad de Alcalá, Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
Mercedes Valiente
Departamento de Química Analítica, Química Física e Ingeniería Química, IQAR, Universidad de Alcalá Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
Javier de la Mata
Departamento de Química Orgánica y Química Inorgánica, IQAR, Universidad de Alcalá, Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
Jesús Cano
Departamento de Química Orgánica y Química Inorgánica, IQAR, Universidad de Alcalá, Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
Rafael Gómez
Departamento de Química Orgánica y Química Inorgánica, IQAR, Universidad de Alcalá, Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of 19F magnetic resonance imaging (19F-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by 19F-MRI.
