Nature Communications (Jul 2021)
Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
- Maik Luu,
- Zeno Riester,
- Adrian Baldrich,
- Nicole Reichardt,
- Samantha Yuille,
- Alessandro Busetti,
- Matthias Klein,
- Anne Wempe,
- Hanna Leister,
- Hartmann Raifer,
- Felix Picard,
- Khalid Muhammad,
- Kim Ohl,
- Rossana Romero,
- Florence Fischer,
- Christian A. Bauer,
- Magdalena Huber,
- Thomas M. Gress,
- Matthias Lauth,
- Sophia Danhof,
- Tobias Bopp,
- Thomas Nerreter,
- Imke E. Mulder,
- Ulrich Steinhoff,
- Michael Hudecek,
- Alexander Visekruna
Affiliations
- Maik Luu
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Zeno Riester
- Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg
- Adrian Baldrich
- Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg
- Nicole Reichardt
- 4DPharma Research Ltd.
- Samantha Yuille
- 4DPharma Research Ltd.
- Alessandro Busetti
- 4DPharma Research Ltd.
- Matthias Klein
- Institute for Immunology, University Medical Center, Johannes Gutenberg University Mainz
- Anne Wempe
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Hanna Leister
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Hartmann Raifer
- Flow Cytometry Core Facility, Philipps University Marburg
- Felix Picard
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Khalid Muhammad
- Department of Biology, United Arab Emirates University
- Kim Ohl
- Department of Pediatrics, RWTH Aachen University
- Rossana Romero
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Florence Fischer
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Christian A. Bauer
- Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, University Hospital Marburg, UKGM, Philipps University Marburg
- Magdalena Huber
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Thomas M. Gress
- Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, University Hospital Marburg, UKGM, Philipps University Marburg
- Matthias Lauth
- Institute of Molecular Biology and Tumor Research, Center for Tumor- and Immunobiology, Philipps-University Marburg
- Sophia Danhof
- Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg
- Tobias Bopp
- Institute for Immunology, University Medical Center, Johannes Gutenberg University Mainz
- Thomas Nerreter
- Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg
- Imke E. Mulder
- 4DPharma Research Ltd.
- Ulrich Steinhoff
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Michael Hudecek
- Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg
- Alexander Visekruna
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- DOI
- https://doi.org/10.1038/s41467-021-24331-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
The activity of immune cells can be regulated by the microbiome. Here, the authors show that the fatty acids pentanoate and butyrate—normally released by the microbiome—increase the anti-tumour activity of cytotoxic T lymphocytes and chimeric antigen receptor T cells through metabolic and epigenetic reprogramming.
