Clinical and Biomedical Research (Jan 2017)

ERK 1/2 activation does not contribute to increased survival mediated by bone marrow cells after 90% partial hepatectomy in Wistar rats

  • Gustavo Alfredo Ochs de Muñoz,
  • Nelson Alexandre Kretzmann,
  • Mónica Luján López,
  • Carlos Oscar Kieling,
  • Carolina Uribe-Cruz,
  • Luciano Basso da Silva,
  • Alessandro Bersch Osvaldt,
  • Ursula da Silveira Matte

Journal volume & issue
Vol. 36, no. 4

Abstract

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We investigated the influence of bone marrow cells upon activation of ERK ½ in an animal model of 90% PH. Phosphorylated ERK 1/2 was evaluated by western blot. No differences were found between the groups. Thus, increased survival does not appear to be mediated by ERK 1/2 activation. Keywords: MAP Kinase Signaling System; stem cells; acute liver failure

Keywords