Nature Communications (Apr 2016)
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
- Qiao Fan,
- Virginie J. M. Verhoeven,
- Robert Wojciechowski,
- Veluchamy A. Barathi,
- Pirro G. Hysi,
- Jeremy A. Guggenheim,
- René Höhn,
- Veronique Vitart,
- Anthony P. Khawaja,
- Kenji Yamashiro,
- S Mohsen Hosseini,
- Terho Lehtimäki,
- Yi Lu,
- Toomas Haller,
- Jing Xie,
- Cécile Delcourt,
- Mario Pirastu,
- Juho Wedenoja,
- Puya Gharahkhani,
- Cristina Venturini,
- Masahiro Miyake,
- Alex W. Hewitt,
- Xiaobo Guo,
- Johanna Mazur,
- Jenifer E. Huffman,
- Katie M. Williams,
- Ozren Polasek,
- Harry Campbell,
- Igor Rudan,
- Zoran Vatavuk,
- James F. Wilson,
- Peter K. Joshi,
- George McMahon,
- Beate St Pourcain,
- David M. Evans,
- Claire L. Simpson,
- Tae-Hwi Schwantes-An,
- Robert P. Igo,
- Alireza Mirshahi,
- Audrey Cougnard-Gregoire,
- Céline Bellenguez,
- Maria Blettner,
- Olli Raitakari,
- Mika Kähönen,
- Ilkka Seppälä,
- Tanja Zeller,
- Thomas Meitinger,
- Janina S. Ried,
- Christian Gieger,
- Laura Portas,
- Elisabeth M. van Leeuwen,
- Najaf Amin,
- André G. Uitterlinden,
- Fernando Rivadeneira,
- Albert Hofman,
- Johannes R. Vingerling,
- Ya Xing Wang,
- Xu Wang,
- Eileen Tai-Hui Boh,
- M. Kamran Ikram,
- Charumathi Sabanayagam,
- Preeti Gupta,
- Vincent Tan,
- Lei Zhou,
- Candice E. H. Ho,
- Wan’e Lim,
- Roger W. Beuerman,
- Rosalynn Siantar,
- E-Shyong Tai,
- Eranga Vithana,
- Evelin Mihailov,
- Chiea-Chuen Khor,
- Caroline Hayward,
- Robert N. Luben,
- Paul J. Foster,
- Barbara E. K. Klein,
- Ronald Klein,
- Hoi-Suen Wong,
- Paul Mitchell,
- Andres Metspalu,
- Tin Aung,
- Terri L. Young,
- Mingguang He,
- Olavi Pärssinen,
- Cornelia M. van Duijn,
- Jie Jin Wang,
- Cathy Williams,
- Jost B. Jonas,
- Yik-Ying Teo,
- David A. Mackey,
- Konrad Oexle,
- Nagahisa Yoshimura,
- Andrew D. Paterson,
- Norbert Pfeiffer,
- Tien-Yin Wong,
- Paul N. Baird,
- Dwight Stambolian,
- Joan E. Bailey Wilson,
- Ching-Yu Cheng,
- Christopher J. Hammond,
- Caroline C. W. Klaver,
- Seang-Mei Saw,
- Consortium for Refractive Error and Myopia (CREAM)
Affiliations
- Qiao Fan
- Singapore Eye Research Institute, Singapore National Eye Centre
- Virginie J. M. Verhoeven
- Department of Ophthalmology, Erasmus Medical Center
- Robert Wojciechowski
- Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health
- Veluchamy A. Barathi
- Singapore Eye Research Institute, Singapore National Eye Centre
- Pirro G. Hysi
- Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine
- Jeremy A. Guggenheim
- School of Optometry and Vision Sciences, Cardiff University
- René Höhn
- Department of Ophthalmology, University Medical Center Mainz
- Veronique Vitart
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Anthony P. Khawaja
- Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine
- Kenji Yamashiro
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- S Mohsen Hosseini
- Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere
- Yi Lu
- Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston
- Toomas Haller
- Estonian Genome Center, University of Tartu
- Jing Xie
- Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne
- Cécile Delcourt
- Université de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement)
- Mario Pirastu
- Institute of Population Genetics, National Research Council
- Juho Wedenoja
- Department of Public Health, University of Helsinki
- Puya Gharahkhani
- Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston
- Cristina Venturini
- Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine
- Masahiro Miyake
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Alex W. Hewitt
- Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne
- Xiaobo Guo
- Department of Statistical Science, School of Mathematics and Computational Science, Sun Yat-Sen University
- Johanna Mazur
- Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz
- Jenifer E. Huffman
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Katie M. Williams
- Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine
- Ozren Polasek
- Faculty of Medicine, University of Split
- Harry Campbell
- Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Igor Rudan
- Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Zoran Vatavuk
- Department of Ophthalmology, Sisters of Mercy University Hospital
- James F. Wilson
- Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Peter K. Joshi
- Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- George McMahon
- MRC Integrative Epidemiology Unit (IEU), University of Bristol
- Beate St Pourcain
- MRC Integrative Epidemiology Unit (IEU), University of Bristol
- David M. Evans
- MRC Integrative Epidemiology Unit (IEU), University of Bristol
- Claire L. Simpson
- Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health
- Tae-Hwi Schwantes-An
- Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health
- Robert P. Igo
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- Alireza Mirshahi
- Department of Ophthalmology, University Medical Center Mainz
- Audrey Cougnard-Gregoire
- Université de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement)
- Céline Bellenguez
- Inserm, U1167
- Maria Blettner
- Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz
- Olli Raitakari
- Research Centre of Applied and Preventive Medicine, University of Turku
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital and School of Medicine, University of Tampere
- Ilkka Seppälä
- Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere
- Tanja Zeller
- Clinic for General and Interventional Cardiology, University Heart Center Hamburg
- Thomas Meitinger
- Institute of Human Genetics, Helmholtz Zentrum München
- Janina S. Ried
- Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Christian Gieger
- Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Laura Portas
- Institute of Population Genetics, National Research Council
- Elisabeth M. van Leeuwen
- Department of Epidemiology, Erasmus Medical Center
- Najaf Amin
- Department of Epidemiology, Erasmus Medical Center
- André G. Uitterlinden
- Department of Epidemiology, Erasmus Medical Center
- Fernando Rivadeneira
- Department of Epidemiology, Erasmus Medical Center
- Albert Hofman
- Department of Epidemiology, Erasmus Medical Center
- Johannes R. Vingerling
- Department of Ophthalmology, Erasmus Medical Center
- Ya Xing Wang
- Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University
- Xu Wang
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems
- Eileen Tai-Hui Boh
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems
- M. Kamran Ikram
- Singapore Eye Research Institute, Singapore National Eye Centre
- Charumathi Sabanayagam
- Singapore Eye Research Institute, Singapore National Eye Centre
- Preeti Gupta
- Singapore Eye Research Institute, Singapore National Eye Centre
- Vincent Tan
- Singapore Eye Research Institute, Singapore National Eye Centre
- Lei Zhou
- Singapore Eye Research Institute, Singapore National Eye Centre
- Candice E. H. Ho
- Singapore Eye Research Institute, Singapore National Eye Centre
- Wan’e Lim
- Department of Ophthalmology, National University Health Systems, National University of Singapore
- Roger W. Beuerman
- Singapore Eye Research Institute, Singapore National Eye Centre
- Rosalynn Siantar
- Singapore Eye Research Institute, Singapore National Eye Centre
- E-Shyong Tai
- Duke-NUS Medical School
- Eranga Vithana
- Singapore Eye Research Institute, Singapore National Eye Centre
- Evelin Mihailov
- Estonian Genome Center, University of Tartu
- Chiea-Chuen Khor
- Singapore Eye Research Institute, Singapore National Eye Centre
- Caroline Hayward
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Robert N. Luben
- Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine
- Paul J. Foster
- Division of Genetics and Epidemiology, UCL Institute of Ophthalmology
- Barbara E. K. Klein
- Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health
- Ronald Klein
- Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health
- Hoi-Suen Wong
- Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto
- Paul Mitchell
- Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, Australia
- Andres Metspalu
- Estonian Genome Center, University of Tartu
- Tin Aung
- Singapore Eye Research Institute, Singapore National Eye Centre
- Terri L. Young
- Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin
- Mingguang He
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University
- Olavi Pärssinen
- Department of Ophthalmology, Central Hospital of Central Finland
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus Medical Center
- Jie Jin Wang
- Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, Australia
- Cathy Williams
- School of Social and Community Medicine, University of Bristol
- Jost B. Jonas
- Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University
- Yik-Ying Teo
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems
- David A. Mackey
- Menzies Research Institute Tasmania, University of Tasmania
- Konrad Oexle
- Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München
- Nagahisa Yoshimura
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Andrew D. Paterson
- Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto
- Norbert Pfeiffer
- Department of Ophthalmology, University Medical Center Mainz
- Tien-Yin Wong
- Singapore Eye Research Institute, Singapore National Eye Centre
- Paul N. Baird
- Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne
- Dwight Stambolian
- Department of Ophthalmology, University of Pennsylvania
- Joan E. Bailey Wilson
- Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health
- Ching-Yu Cheng
- Singapore Eye Research Institute, Singapore National Eye Centre
- Christopher J. Hammond
- Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine
- Caroline C. W. Klaver
- Department of Ophthalmology, Erasmus Medical Center
- Seang-Mei Saw
- Singapore Eye Research Institute, Singapore National Eye Centre
- Consortium for Refractive Error and Myopia (CREAM)
- DOI
- https://doi.org/10.1038/ncomms11008
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.
