Nature Communications (Oct 2022)
Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development
- Kosei Nagata,
- Hironori Hojo,
- Song Ho Chang,
- Hiroyuki Okada,
- Fumiko Yano,
- Ryota Chijimatsu,
- Yasunori Omata,
- Daisuke Mori,
- Yuma Makii,
- Manabu Kawata,
- Taizo Kaneko,
- Yasuhide Iwanaga,
- Hideki Nakamoto,
- Yuji Maenohara,
- Naohiro Tachibana,
- Hisatoshi Ishikura,
- Junya Higuchi,
- Yuki Taniguchi,
- Shinsuke Ohba,
- Ung-il Chung,
- Sakae Tanaka,
- Taku Saito
Affiliations
- Kosei Nagata
- Sensory & Motor System Medicine, The University of Tokyo
- Hironori Hojo
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Song Ho Chang
- Sensory & Motor System Medicine, The University of Tokyo
- Hiroyuki Okada
- Sensory & Motor System Medicine, The University of Tokyo
- Fumiko Yano
- Bone and Cartilage Regenerative Medicine, The University of Tokyo
- Ryota Chijimatsu
- Bone and Cartilage Regenerative Medicine, The University of Tokyo
- Yasunori Omata
- Sensory & Motor System Medicine, The University of Tokyo
- Daisuke Mori
- Bone and Cartilage Regenerative Medicine, The University of Tokyo
- Yuma Makii
- Sensory & Motor System Medicine, The University of Tokyo
- Manabu Kawata
- Sensory & Motor System Medicine, The University of Tokyo
- Taizo Kaneko
- Sensory & Motor System Medicine, The University of Tokyo
- Yasuhide Iwanaga
- Sensory & Motor System Medicine, The University of Tokyo
- Hideki Nakamoto
- Sensory & Motor System Medicine, The University of Tokyo
- Yuji Maenohara
- Sensory & Motor System Medicine, The University of Tokyo
- Naohiro Tachibana
- Sensory & Motor System Medicine, The University of Tokyo
- Hisatoshi Ishikura
- Sensory & Motor System Medicine, The University of Tokyo
- Junya Higuchi
- Sensory & Motor System Medicine, The University of Tokyo
- Yuki Taniguchi
- Sensory & Motor System Medicine, The University of Tokyo
- Shinsuke Ohba
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Ung-il Chung
- Department of Cell Biology, Institute of Biomedical Sciences, Nagasaki University
- Sakae Tanaka
- Sensory & Motor System Medicine, The University of Tokyo
- Taku Saito
- Sensory & Motor System Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-022-33744-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Possible distinct contributions of Runx 2 and Runx3 in osteoarthritis have not been clarified. Nagata et al. show that Runx3 protects adult articular cartilage by extracellular matrix protein production in normal conditions, while Runx2 exerts both catabolic and anabolic effects during inflammation.
