Structure of the intact ATM/Tel1 kinase

Xuejuan Wang; Huanyu Chu; Mengjuan Lv; Zhihui Zhang; Shuwan Qiu; Haiyan Liu; Xuetong Shen; Weiwu Wang; Gang Cai

doi:10.1038/ncomms11655

Nature Communications (May 2016)

Structure of the intact ATM/Tel1 kinase

Xuejuan Wang,
Huanyu Chu,
Mengjuan Lv,
Zhihui Zhang,
Shuwan Qiu,
Haiyan Liu,
Xuetong Shen,
Weiwu Wang,
Gang Cai

Affiliations

Xuejuan Wang: Key Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University
Huanyu Chu: School of Life Sciences, University of Science and Technology of China
Mengjuan Lv: School of Life Sciences, University of Science and Technology of China
Zhihui Zhang: School of Life Sciences, University of Science and Technology of China
Shuwan Qiu: School of Life Sciences, University of Science and Technology of China
Haiyan Liu: School of Life Sciences, University of Science and Technology of China
Xuetong Shen: Department of Epigenetics and Molecular Carcinogenesis, University of Texas M.D. Anderson Cancer Center
Weiwu Wang: Key Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University
Gang Cai: School of Life Sciences, University of Science and Technology of China

DOI: https://doi.org/10.1038/ncomms11655
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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The ataxia-telangiectasia mutated (ATM) protein kinase is a key player in the response to DNA damage and is essential for the maintenance of cellular homeostasis. Here the authors describe the cryo-EM structure of ATM/Tel1 from fission yeast that suggests how dimerization regulates its activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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