Immune-Inflammatory Response in Lifespan—What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study
Giulia Accardi,
Anna Calabrò,
Rosalia Caldarella,
Calogero Caruso,
Marcello Ciaccio,
Marta Di Simone,
Mattia Emanuela Ligotti,
Serena Meraviglia,
Rosa Zarcone,
Giuseppina Candore,
Anna Aiello
Affiliations
Giulia Accardi
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy
Anna Calabrò
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy
Rosalia Caldarella
Department of Laboratory Medicine, University Hospital “P. Giaccone”, 90127 Palermo, Italy
Calogero Caruso
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy
Marcello Ciaccio
Department of Laboratory Medicine, University Hospital “P. Giaccone”, 90127 Palermo, Italy
Marta Di Simone
Central Laboratory of Advanced Diagnosis and Biomedical Research, University Hospital “P. Giaccone”, 90127 Palermo, Italy
Mattia Emanuela Ligotti
ISMETT-IRCCS Mediterranean Institute for Transplants and Highly Specialised Therapies, 90127 Palermo, Italy
Serena Meraviglia
Central Laboratory of Advanced Diagnosis and Biomedical Research, University Hospital “P. Giaccone”, 90127 Palermo, Italy
Rosa Zarcone
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy
Giuseppina Candore
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy
Anna Aiello
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy
Studying models of healthy aging and exceptional longevity is crucial to understanding a possible longevity signature, as most show resistance to age-related diseases. In particular, semi- and supercentenarians are a highly selected group, having survived significant adversities, including the Spanish flu and COVID-19 pandemics, indicating distinctive immune system characteristics. This paper analyzes the inflammatory scores (INFLA-score, Systemic Inflammation Response Index (SIRI)) and Aging-Related Immune Phenotype (ARIP) indicators calculated from the dataset of the DESIGN project, including 249 participants aged 19–111 years, aiming to understand the immune-inflammatory (IMFLAM) role in achieving longevity. Statistical analyses, including linear regression and one-way ANOVA, were performed to explore the correlations between these parameters and age. Both INFLA-score and SIRI showed a significant increase with age. However, no statistical differences were found when comparing the values of semi- and supercentenarians to other age groups, which are similar to adults and lower than younger centenarians. Regarding ARIP values, it is noteworthy that when comparing the CD8+ Naïve/Effector scores between groups, no significant differences were observed between the semi- and supercentenarian group and the other groups. These results support the idea that the control of IMFLAM response can promote extreme longevity.
