New Insights into Health Conditions Related to Malfunctions in Clock Genes
Kaja Majewska,
Mikołaj Seremak,
Katarzyna Podhorodecka,
Maria Derkaczew,
Bartosz Kędziora,
Paulina Boniecka,
Kamila Zglejc-Waszak,
Agnieszka Korytko,
Małgorzata Pawłowicz,
Joanna Wojtkiewicz
Affiliations
Kaja Majewska
Warmian-Masurian Cancer Center of the Ministry of the Interior and Administration Hospital, 10-228 Olsztyn, Poland
Mikołaj Seremak
Students’ Scientific Club of Pathophysiology, Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Katarzyna Podhorodecka
Students’ Scientific Club of Pathophysiology, Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Maria Derkaczew
Students’ Scientific Club of Pathophysiology, Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Bartosz Kędziora
Students’ Scientific Club of Pathophysiology, Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Paulina Boniecka
Students’ Scientific Club of Pathophysiology, Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Kamila Zglejc-Waszak
Department of Anatomy, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Agnieszka Korytko
Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Małgorzata Pawłowicz
Department of Pediatric Neurogenetics and Rare Diseases, Prof. Dr. Stanislaw Popowski Regional Specialized Children’s Hospital, 10-561 Olsztyn, Poland
Joanna Wojtkiewicz
Students’ Scientific Club of Pathophysiology, Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Chronotypes play a crucial role in regulating sleep–wake cycles and overall health. The aim of this study was to investigate chronotype, sleep quality, polymorphisms of clock genes and the level of leptin in serum. We used standardized questionnaires to assess chronotype and sleep quality. Genetic analysis was performed to determine the selected clock gene polymorphism. Serum leptin level was measured by the Elisa method. The results showed that serum leptin concentration was elevated in women, as well as in men who had a high waist-to-hip ratio (WHR) and body mass index (BMI). The evidence indicated that younger students (T (rs2735611) and PER2 c.-12C>G (rs2304672) genes were associated with serum leptin level and chronotype, respectively. These findings provide insights into the relationships between chronotype, sleep quality, clock gene polymorphisms and obesity risk in biomedical students. Understanding these factors can contribute to better sleep management and potential interventions to improve health outcomes in humans.
