BORIC ACID AMELIORATES LIVER INJURY IN RAT INDUCED BY CYCLOPHOSPHAMIDE

Abstract

Introduction: The aim of the current study was to look into any potential ameliorative benefits of boric acid on liver damage in rats caused by cyclophosphamide (CTX). Materials and Methods: Four groups; control, boric acid, CTX, and boric acid + CTX, were created. Female Wistar albino rats were given daily injections of CTX (75 mg/kg) to create the liver damage model. Cyclophosphamide (75 mg/kg) was administered intraperitoneally, and boron (1.3 g/rat/day) was administered by gavage every day for two weeks in the boric acid+CTX group. The histopathological changes were evaluated in ovarian tissue staining with hematoxylin and eosin, masson tricrom, and periodic acid Schiff. We assessed ovarian tissue enzyme activity as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Results: Images in the boric acid+CTX group had lower histological evaluations than those in the CTX group under the light microscope. According to the findings, boric acid reduced the levels of malondialdehyde (MDA) in the liver tissues. Additionally, boric acid improved the actions of oxidative stress indicators to reduce oxidative stress brought on by CTX and upregulated antioxidant parameters. Conclusion: In conclusion, our study have demonstrated that CTX- induced liver injury can be alleviated by reducing the tissue MDA levels, increasing the liver’s SOD, GSH-Px, and CAT activities. In order to reduce the liver damage caused by CTX, boric acid may be administered as a dietary supplement or functional food.

Keywords

• boric acid
• cyclophosphamide
• liver injury
• borik asit
• karaciğer hasarı
• siklofosfamid