Extranodal NK/T-cell lymphoma: a review of literature and case report

Abstract

Extranodal NK/T-cell lymphoma – a rare lymphoproliferative disease characterized predominantly by extranodal localization, aggressive course and low efficiency of conventional chemotherapy. Clinical presentation is diverse and depends on tumor lesion localization. In this article, a literature review and case report of patient with generalized extranodal NK/T-cell lymphoma with bone marrow involvement, unusual intracranial tumor localization, tumor leukemization and central nervous system-leukemia were presented. Adequate treatment strategy made it possible to achieve long-term complete remission in a patient with poor prognosis.

Keywords

• extranodal nk/т-cell lymphoma
• immunohistochemistry
• clonal rearrangements
• chemotherapy
• allogeneic unrelated hematopoietic stem cell transplantation