Anti-Kv1.4 Antibody Without Myasthenia Gravis

Naoto Kuyama, MD; Seiji Takashio, MD, PhD; Takumi Nagakura, MD; Michie Imamura, MD; Koutaro Takamatsu, MD, PhD; Masafumi Takae, MD, PhD; Kyoko Hirakawa, MD, PhD; Kenshi Yamanaga, MD, PhD; Shinsuke Hanatani, MD, PhD; Eiichiro Yamamoto, MD, PhD; Kenichi Matsushita, MD, PhD; Mitsuharu Ueda, MD, PhD; Kenichi Tsujita, MD, PhD

doi:10.1016/j.jaccas.2023.101734

JACC: Case Reports (Mar 2023)

Anti-Kv1.4 Antibody Without Myasthenia Gravis

Naoto Kuyama, MD,
Seiji Takashio, MD, PhD,
Takumi Nagakura, MD,
Michie Imamura, MD,
Koutaro Takamatsu, MD, PhD,
Masafumi Takae, MD, PhD,
Kyoko Hirakawa, MD, PhD,
Kenshi Yamanaga, MD, PhD,
Shinsuke Hanatani, MD, PhD,
Eiichiro Yamamoto, MD, PhD,
Kenichi Matsushita, MD, PhD,
Mitsuharu Ueda, MD, PhD,
Kenichi Tsujita, MD, PhD

Affiliations

Naoto Kuyama, MD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Seiji Takashio, MD, PhD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Address for correspondence: Dr Seiji Takashio, Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Takumi Nagakura, MD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Michie Imamura, MD: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Koutaro Takamatsu, MD, PhD: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Masafumi Takae, MD, PhD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Kyoko Hirakawa, MD, PhD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Kenshi Yamanaga, MD, PhD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Shinsuke Hanatani, MD, PhD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Eiichiro Yamamoto, MD, PhD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Kenichi Matsushita, MD, PhD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Mitsuharu Ueda, MD, PhD: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Kenichi Tsujita, MD, PhD: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

DOI: https://doi.org/10.1016/j.jaccas.2023.101734
Journal volume & issue: Vol. 9
p. 101734

Abstract

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Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis. In both cases, anti-Kv1.4 antibody was positive despite the absence of thymoma and anti-acetylcholine receptor antibody, and immunosuppressants eventually resolved their symptoms and cardiac function. (Level of Difficulty: Advanced.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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