JACC: Case Reports (Mar 2023)
Anti-Kv1.4 Antibody Without Myasthenia Gravis
- Naoto Kuyama, MD,
- Seiji Takashio, MD, PhD,
- Takumi Nagakura, MD,
- Michie Imamura, MD,
- Koutaro Takamatsu, MD, PhD,
- Masafumi Takae, MD, PhD,
- Kyoko Hirakawa, MD, PhD,
- Kenshi Yamanaga, MD, PhD,
- Shinsuke Hanatani, MD, PhD,
- Eiichiro Yamamoto, MD, PhD,
- Kenichi Matsushita, MD, PhD,
- Mitsuharu Ueda, MD, PhD,
- Kenichi Tsujita, MD, PhD
Affiliations
- Naoto Kuyama, MD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Seiji Takashio, MD, PhD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Address for correspondence: Dr Seiji Takashio, Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
- Takumi Nagakura, MD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Michie Imamura, MD
- Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Koutaro Takamatsu, MD, PhD
- Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Masafumi Takae, MD, PhD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Kyoko Hirakawa, MD, PhD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Kenshi Yamanaga, MD, PhD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Shinsuke Hanatani, MD, PhD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Eiichiro Yamamoto, MD, PhD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Kenichi Matsushita, MD, PhD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Mitsuharu Ueda, MD, PhD
- Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Kenichi Tsujita, MD, PhD
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
- Journal volume & issue
-
Vol. 9
p. 101734
Abstract
Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis. In both cases, anti-Kv1.4 antibody was positive despite the absence of thymoma and anti-acetylcholine receptor antibody, and immunosuppressants eventually resolved their symptoms and cardiac function. (Level of Difficulty: Advanced.)
