Nature Communications (Jun 2019)

Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion

  • Kossay Zaoui,
  • Zied Boudhraa,
  • Paul Khalifé,
  • Euridice Carmona,
  • Diane Provencher,
  • Anne-Marie Mes-Masson

DOI
https://doi.org/10.1038/s41467-019-10570-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Ran, a nucleus-cytoplasm shuttle protein, is implicated in cancer development and survival. Here, the authors show that Ran binds RhoA to impair its degradation and allow its localisation to the plasma membrane of ovarian cancer cells for tumour invasion.