The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer

Andrew O. Yam; Andrew O. Yam; Tatyana Chtanova; Tatyana Chtanova

doi:10.3389/fimmu.2019.00386

Frontiers in Immunology (Mar 2019)

The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer

Andrew O. Yam,
Andrew O. Yam,
Tatyana Chtanova,
Tatyana Chtanova

Affiliations

Andrew O. Yam: Immunology Division, Garvan Institute of Medical Research, Sydney, NSW, Australia
Andrew O. Yam: Faculty of Medicine, St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia
Tatyana Chtanova: Immunology Division, Garvan Institute of Medical Research, Sydney, NSW, Australia
Tatyana Chtanova: Faculty of Medicine, St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia

DOI: https://doi.org/10.3389/fimmu.2019.00386
Journal volume & issue: Vol. 10

Abstract

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Recent studies of the patterns of chemokine-mediated immune cell recruitment into solid tumors have enhanced our understanding of the role played by various immune cell subsets both in amplifying and inhibiting tumor cell growth and spread. Here we discuss how the chemokine/chemokine receptor networks bring together immune cells within the microenvironment of skin tumors, particularly melanomas, including their effect on disease progression, prognosis and therapeutic options.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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