Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity

Shuwen He; John P. Gillies; Juliana L. Zang; Carmen M. Córdoba-Beldad; Io Yamamoto; Yasuhiro Fujiwara; Julie Grantham; Morgan E. DeSantis; Hiroki Shibuya

doi:10.1038/s41467-023-37370-7

Nature Communications (Mar 2023)

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity

Shuwen He,
John P. Gillies,
Juliana L. Zang,
Carmen M. Córdoba-Beldad,
Io Yamamoto,
Yasuhiro Fujiwara,
Julie Grantham,
Morgan E. DeSantis,
Hiroki Shibuya

Affiliations

Shuwen He: Department of Chemistry and Molecular Biology, University of Gothenburg
John P. Gillies: Department of Molecular, Cellular, and Developmental Biology, University of Michigan
Juliana L. Zang: Department of Molecular, Cellular, and Developmental Biology, University of Michigan
Carmen M. Córdoba-Beldad: Department of Chemistry and Molecular Biology, University of Gothenburg
Io Yamamoto: Department of Chemistry and Molecular Biology, University of Gothenburg
Yasuhiro Fujiwara: Institute for Quantitative Biosciences, University of Tokyo
Julie Grantham: Department of Chemistry and Molecular Biology, University of Gothenburg
Morgan E. DeSantis: Department of Molecular, Cellular, and Developmental Biology, University of Michigan
Hiroki Shibuya: Department of Chemistry and Molecular Biology, University of Gothenburg

DOI: https://doi.org/10.1038/s41467-023-37370-7
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

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Male meiosis relies on canonical centrosomes for spindle formation, but how this differs from acentrosomal oocyte meiosis is unclear. Here they show that spindle formation in sperm relies on DYNLRB2, similar to the activity of DYNLRB1 in mitotic cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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