Correlation of serum concentration cyclin-dependent kinase 4 and cyclin-dependent kinase 6 with breast cancer in Babylon province

Abstract

Objectives: The goal of this study to estimate the correlation between breast cancer and cyclin-dependent kinase 4 (CDK4)\CDK6 enzyme concentrations in the occurrence of breast cancer and breast cancer subtypes. Methods: A total of 80 breast cancer patients are subdivided according to molecular classification into four groups, Luminal A, Luminal B, Her2/neu enriched, and TPN and 80 healthy individuals as control were enrolled; biochemical tests and body mass index were assayed. Results: No significant differences were found between patients and control groups and no significant differences were found among breast cancer subtypes in the concentrations of CDK4 (P > 0.05). There were no significant differences found between patients and control groups and no significant difference in the CDK6 concentration among subtypes groups (P > 0.05). The correlation between age, CDK4, and CDK6 in cases and control revealed that the correlation was absent between age, CDK4, and CDK6 concentration, except a weak positive correlation was found between CDK4 and CDK6 concentrations. Conclusion: There was no significant difference in serum levels of CDK4 and serum level of CDK6 between case and control and among patient subtypes.

Keywords

• breast cancer
• cell cycle
• cyclin-dependent kinase 4 and cyclin-dependent kinase 6
• immunohistochemistry classification immunohistochemistry
• retinoblastoma protein