The possible link between periodontitis and orodigestive cancer: An overview

Abstract

Increasing evidences are found in the literature lately regarding the association between periodontitis and orodigestive tract cancers. Periodontopathic bacteria resulting in periodontal disease, acts as a risk factor for the initiation and development of carcinoma. They have been shown to act through various mechanisms including inhibition of apoptosis, activation of cellular proliferation, and others. This review is an attempt to find the possible connecting mechanism between the aforesaid.

Keywords

• fusobacterium nucleatum
• orodigestive cancer
• periodontitis
• porphyromonas gingivalis
• treponema denticola