Nature Communications (Dec 2017)

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

  • Huiming Lu,
  • Raghavendra A. Shamanna,
  • Jessica K. de Freitas,
  • Mustafa Okur,
  • Prabhat Khadka,
  • Tomasz Kulikowicz,
  • Priscella P. Holland,
  • Jane Tian,
  • Deborah L. Croteau,
  • Anthony J. Davis,
  • Vilhelm A. Bohr

DOI
https://doi.org/10.1038/s41467-017-02146-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

DNA double-strand break (DSB) repair is a tightly regulated process that can occur via non-homologous end joining (NHEJ) or homologous recombination (HR). Here, the authors investigate how RECQL4 modulates DSB repair pathway choice by differentially regulating NHEJ and HR in a cell cycle-dependent manner.