Toxicity and therapeutic efficacy of injections based on еnrofloxacin and colistin

Abstract

We studied the acute and sub-chronical toxicity of the drugs on the basis of еnrofloxacin and colistin in laboratory animals. The drug according to GOST 12.1.007-76 apply to Class 3 danger - little dangerous. We studied the influence of the drug on the basis of composite еnrofloxacin and colistin at doses 0,5, 1,0 and 5,0 ml per 10 kg body weight on the clinical and biochemical indicators of the blood in piglets and calves. It was found that the therapeutical efficacy of new drug with kolibakterioze calves equaled 90,7%, piglets - 91,4%, while the effectiveness dizparcolum (base product) was 78,9% and 80,0% respectively.

Keywords

• энрофлоксацин
• колистин
• острая и субхроническая токсичность
• колибактериоз
• поросята
• телята
• терапевтическая эффективность
• еnrofloxacin