Synthesis of Gibberellic Acid Derivatives and Their Effects on Plant Growth

Abstract

A series of novel C-3-OH substituted gibberellin derivatives bearing an amide group were designed and synthesized from the natural product gibberellic acid (GA3). Their activities on the plant growth regulation of rice and Arabidopsis were evaluated in vivo. Among these compounds, 10d and 10f exhibited appreciable inhibitory activities on rice (48.6% at 100 μmol/L) and Arabidopsis (41.4% at 100 μmol/L), respectively. These results provide new insights into the design and synthesis of potential plant growth regulators.

Keywords

• gibberellin derivatives
• natural products
• Huisgen reaction
• amide
• plant growth regulators