Semicarbazide-sensitive amine oxidase activity levels in patients with acute lymphoblastic leukemia after cytotoxic chemotherapy

Abstract

Background: The role of Semicarbazide-sensitive amine oxidase (SSAO) in carcinogenesis is unknown; however, due to its function it may be involved in tumorigenesis via production of reactive aldehydes and hydrogen peroxide. Objective: The study aimed to assess serum SSOA activity and to investigate the effect of cytotoxic chemotherapy on liver function in patients with acute lymphoblastic leukemia (ALL). Materials and Methods: Samples from 25 children with ALL were taken before and after finishing the induction phase of chemotherapy with (Daunorubicin, Vincristine VRC, L-asparaginase, Cyclophosphamide, Cytosar, Dexon, and Adriamycin). Activity of SSAO and liver function tests (alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP) and total serum bilirubin TSB) were measured using colorimetric methods before and after treatment. Results: Significant lower level in SSOA activity was found in 68% of the patients (P < 0.05) after chemotherapy. Significant higher levels were found after chemotherapy in ALT, AST, ALP activities and TSB levels in 92%, 80%, 72%, and 80% of the patients respectively. Conclusion: The decrease in SSAO activities after chemotherapy could be a mechanism for preventing the formation of the pro-inflammatory byproducts of SSAO. The increase in liver function could be a response to chemotherapy metabolism in liver cells. Keywords: Semicarbazide-sensitive amine oxidase, Liver function, Acute lymphoblastic leukemia, Chemotherapy, Cytotoxic effects