Light-activated NIR-II imaging-guided tumor therapy with enhanced HPTT/starvation cycle

Gui-long Wu; Senyou Tan; Juan Wu; Feirong Wang; Xiaofeng Tan; Guodong Chen; Qinglai Yang

Materials & Design (Apr 2024)

Light-activated NIR-II imaging-guided tumor therapy with enhanced HPTT/starvation cycle

Gui-long Wu,
Senyou Tan,
Juan Wu,
Feirong Wang,
Xiaofeng Tan,
Guodong Chen,
Qinglai Yang

Affiliations

Gui-long Wu: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, People's Republic of China; Corresponding authors at: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China (X. Tan and Q. Yang).
Senyou Tan: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, People's Republic of China
Juan Wu: Hunan Polytechnic of Environment and Biology, Hengyang, Hunan 421001, People's Republic of China
Feirong Wang: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, People's Republic of China
Xiaofeng Tan: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, People's Republic of China; National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, Hunan, People's Republic of China; MOE Key Lab of Rare Pediatric Diseases, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, People's Republic of China; Hunan Polytechnic of Environment and Biology, Hengyang, Hunan 421001, People's Republic of China; Corresponding authors at: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China (X. Tan and Q. Yang).
Guodong Chen: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, People's Republic of China; Corresponding authors at: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China (X. Tan and Q. Yang).
Qinglai Yang: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, People's Republic of China; National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, Hunan, People's Republic of China; MOE Key Lab of Rare Pediatric Diseases, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, People's Republic of China; Hunan Polytechnic of Environment and Biology, Hengyang, Hunan 421001, People's Republic of China; Corresponding authors at: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China (X. Tan and Q. Yang).

Journal volume & issue: Vol. 240
p. 112815

Abstract

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Establishing a phototheranostic platform constructed by the second near-infrared (NIR-II) region has proved a revolutionary and promising strategy for cancer treatment. However, the antitumor effectiveness is severely limited by the monotonicity of the NIR-photothermal therapy (HPTT) modality and tumor thermotolerance caused by the production of heat shock proteins (HSPs). Here, a minimalistic approach is used to construct an organic nanoplatform (IFT@PEG-GOX NPs) with the reciprocal cyclic promotion of hypothermia and starvation treatments for NIR-II imaging-guided tumor therapy. After the enhanced permeability and retention (EPR) effect causes IFT@PEG-GOX NPs to accumulate in tumors, glucose oxidase (GOx)-mediated tumor starvation may obstruct the production of adenosine triphosphate (ATP) and downregulation heat shock proteins (HSPs), thereby reducing the thermotolerance of cells. After that, sensitized HPTT was activated and GOx's catalytic activity was increased by NIR laser irradiation. Then, there would be a subsequent, intensified inhibition of HSP along with an additional amplification of the GOx-mediated tumor starvation. As a consequence, the HPTT/Starvation therapy (ST) bidirectional cycle method is initiated, leading to a bidirectional cyclic enhancing impact of HPTT and ST and significantly better tumor suppression.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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