Iron-catalyzed synthesis of N-heterocycles via intermolecular and intramolecular cyclization reactions: A review

Abstract

Small N-heterocyclic molecules are important scaffolds in the pharmaceutical industry and most FDA-approved drugs are nitrogen-containing heterocycles. Chemists try to employ iron-based catalysts for organic transformations due to their abundance, economic, easily accessible and environment-friendly behaviour. N-heterocycles are synthesized by the cyclization reactions. This review covered the synthesis of N-heterocycles by employing iron-based catalysts via intermolecular or intramolecular cyclizations.

Keywords

• Iron, catalyst
• N-heterocycles
• Intermolecular
• Intramolecular