miR-762 can negatively regulate menin in ovarian cancer

Abstract

Rui Hou,1 Zhuo Yang,1 ShiZhuo Wang,1 DaMing Chu,1 Qifang Liu,1 Jia Liu,1 Luo Jiang2 1Department of Obstetrics and Gynecology, 2Department of Ultrasound, Shengjing Hospital Affiliated to China Medical University, Shenyang, People’s Republic of China Abstract: Ovarian cancer accounts for the major part of the mortality attributable to female reproductive system malignant tumors worldwide. Recently, the incidence of ovarian cancer has been increasing annually, and there remains a lack of suitable treatment methods that can significantly improve the 5-year survival rates of patients. Therefore, it is necessary to identify more effective treatments for ovarian cancer. It is established that microRNAs (miRNAs) have important roles in the diagnosis and treatment of ovarian cancer and a specific miRNA, miR-762, can promote the development of a variety of tumors. Menin is encoded by MEN1, a tumor suppressor gene, that is usually downregulated in ovarian cancer. In this study, we evaluated the expression levels of miR-762 and menin in ovarian cancer tissues and demonstrated that they were correlated. In addition, we found that miR-762 can downregulate the expression of menin through a binding site in its 3'-UTR and consequently upregulate the Wnt cell signaling pathway to promote the development of ovarian cancer. These results indicate that miR-762 is a promising potential target for the treatment of ovarian cancer. Keywords: miR-762, menin, ovarian cancer 

Keywords

• miR-762
• menin
• ovarian cancer