Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP Levels
Ruxandra Maria Christodorescu,
Daniel Miron Brie,
Alina Diduța Brie,
Samuel Nistor,
Alexandru Tîrziu,
Angela Dragomir,
Cristian Mornoș,
Simona Drăgan,
Daniel Duda-Seiman,
Adina Pop-Moldovan,
Dan Dărăbanțiu
Affiliations
Ruxandra Maria Christodorescu
Department of Internal Medicine, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
Daniel Miron Brie
Research Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, Romania
Alina Diduța Brie
Department of Cell and Molecular Biology, “Victor Babes” University of Medicine and Pharmacy, Tudor Vladimirescu Street, No. 14, 300174 Timisoara, Romania
Samuel Nistor
Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, Romania
Alexandru Tîrziu
Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, Romania
Angela Dragomir
Research Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, Romania
Cristian Mornoș
Research Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, Romania
Simona Drăgan
Research Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, Romania
Daniel Duda-Seiman
Research Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, Romania
Adina Pop-Moldovan
Faculty of Medicine, “Vasile Goldis” Western University of Arad, Revolutiei Bvd., No. 174, 310025 Arad, Romania
Dan Dărăbanțiu
Arad County Emergency Clinical Hospital, 310158 Arad, Romania
Background: NT-proBNP levels with a wide range at admission play both a diagnostic and a prognostic role in patients with HF. The differences regarding the clinical profiles and demography in decompensated HF patients according to NT-proBNP levels at admission are not clear. Methods: This study aimed to analyze and compare clinical profiles and demographics in patients hospitalized for decompensated heart failure according to levels of NT-proBNP at admission. The study included 302 patients hospitalized for decompensated HF who were divided into three groups based on admission NT-proBNP levels: group A (n = 46, with NT-proBNP level 10,000 pg/mL). Results: Patients hospitalized with decompensated HF and very high levels of NTproBNP, above 10,000 pg/mL at admission, are older, have a lower LVEF, higher NYHA class, more renal dysfunction, and longer hospital stay, resulting in a more severe clinical profile. Conclusions: The presence of very high levels of NT-proBNP may identify a category of patients with a more severe prognosis that requires more aggressive management and closer follow-up.
