Thrombocytopenia Associated MultiOrgan Failure: A Fatal Complication of Diabetes Ketoacidosis

Abstract

Thrombocytopenia Associated Multiple Organ Failure (TAMOF) is an extremely rare fatal thrombotic microangiopathic disorder in children that can occur in association with Diabetes Ketoacidosis (DKA). An 11-year-old adolescent boy presented with severe DKA and later on he developed severe thrombocytopenia, intrinsic renal failure and pulmonary haemorrhage. The clinical picture was most consistent with TAMOF. The clinical condition, renal function test and platelet counts were gradually improved after multiple transfusion of fresh frozen plasma. A high index of suspicion of TAMOF is required in children with DKA who present with severe TAMOF. Plasma transfusion is suggested to be a life-saving intervention in a child with TAMOF secondary to DKA.

Keywords

• child
• plasma transfusion
• renal failure