Медицинская иммунология (Jul 2014)

BLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME

  • T. V. Kopytova,
  • N. A. Dobrotyna,
  • L. N. Himkina,
  • N. A. Shelchkova,
  • G. A. Panteleeva

DOI
https://doi.org/10.15789/1563-0625-2011-2-3-205-210
Journal volume & issue
Vol. 13, no. 2-3
pp. 205 – 210

Abstract

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Abstract. The article presents data about blood serum cytokine profile in patients with chronic widespread dermatoses, associated with increase in blood markers of endogenous intoxication (EI) syndrome, i.e., lowand medium-molecular mass substances (LMWS). A close interrelation has been revealed between EI levels, and cytokine profiles. In the patients with high amounts of blood LMWS, increased levels of anti-inflammatory IL have been shown. Correlation analysis of clinical and laboratory parameters has demonstrated a leading role of EI in pathogenetic mechanisms of chronic extended dermatoses, and brings about altered regulation of metabolic processes. A severe clinical course of dermatoses (i.e., therapy resistance) was associated with a considerable decrease in blood IL-8 and IL-10 levels, along with high IgE and LMWS amounts. (Med. Immunol., 2011, vol. 13, N 2-3, pp 205-210)

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