Nature Communications (Nov 2021)
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer
- Pauliina M. Munne,
- Lahja Martikainen,
- Iiris Räty,
- Kia Bertula,
- Nonappa,
- Janika Ruuska,
- Hanna Ala-Hongisto,
- Aino Peura,
- Babette Hollmann,
- Lilya Euro,
- Kerim Yavuz,
- Linda Patrikainen,
- Maria Salmela,
- Juho Pokki,
- Mikko Kivento,
- Juho Väänänen,
- Tomi Suomi,
- Liina Nevalaita,
- Minna Mutka,
- Panu Kovanen,
- Marjut Leidenius,
- Tuomo Meretoja,
- Katja Hukkinen,
- Outi Monni,
- Jeroen Pouwels,
- Biswajyoti Sahu,
- Johanna Mattson,
- Heikki Joensuu,
- Päivi Heikkilä,
- Laura L. Elo,
- Ciara Metcalfe,
- Melissa R. Junttila,
- Olli Ikkala,
- Juha Klefström
Affiliations
- Pauliina M. Munne
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Lahja Martikainen
- Department of Applied Physics, Molecular Materials Group, Aalto University School of Science
- Iiris Räty
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Kia Bertula
- Department of Applied Physics, Molecular Materials Group, Aalto University School of Science
- Nonappa
- Department of Applied Physics, Molecular Materials Group, Aalto University School of Science
- Janika Ruuska
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Hanna Ala-Hongisto
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Aino Peura
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Babette Hollmann
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Lilya Euro
- Research Program of Stem Cells and Metabolism, Biomedicum Helsinki, University of Helsinki
- Kerim Yavuz
- Applied Tumor Genomics Research Program, Enhancer Biology Laboratory, Faculty of Medicine, University of Helsinki
- Linda Patrikainen
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Maria Salmela
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Juho Pokki
- Department of Electrical Engineering and Automation, Aalto University
- Mikko Kivento
- Applied Tumor Genomics Research Program, Faculty of Medicine, Oncogenomics Laboratory, University of Helsinki
- Juho Väänänen
- Applied Tumor Genomics Research Program, Faculty of Medicine, Oncogenomics Laboratory, University of Helsinki
- Tomi Suomi
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Liina Nevalaita
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Minna Mutka
- Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki
- Panu Kovanen
- Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki
- Marjut Leidenius
- Breast Surgery Unit, Helsinki University Central Hospital
- Tuomo Meretoja
- Breast Surgery Unit, Helsinki University Central Hospital
- Katja Hukkinen
- Department of Mammography, Helsinki University Central Hospital
- Outi Monni
- Applied Tumor Genomics Research Program, Faculty of Medicine, Oncogenomics Laboratory, University of Helsinki
- Jeroen Pouwels
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- Biswajyoti Sahu
- Applied Tumor Genomics Research Program, Enhancer Biology Laboratory, Faculty of Medicine, University of Helsinki
- Johanna Mattson
- Department of Oncology, University of Helsinki & Helsinki University Hospital
- Heikki Joensuu
- Department of Oncology, University of Helsinki & Helsinki University Hospital
- Päivi Heikkilä
- Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki
- Laura L. Elo
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Ciara Metcalfe
- Genentech Inc.
- Melissa R. Junttila
- Genentech Inc.
- Olli Ikkala
- Department of Applied Physics, Molecular Materials Group, Aalto University School of Science
- Juha Klefström
- Finnish Cancer Institute, FICAN South Helsinki University Hospital & Translational Cancer Medicine, Medical Faculty, University of Helsinki. Cancer Cell Circuitry Laboratory, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki
- DOI
- https://doi.org/10.1038/s41467-021-27220-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Reliable luminal estrogen receptor (ERα+) breast cancer models are limited. Here, the authors use patient derived breast epithelial and breast cancer explant cultures grown in several extracellular matrix scaffolds and show that ERα expression is regulated by matrix stiffness via stress-mediated p38 activation and H3K27me3-mediated epigenetic regulation.
