Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes

Hanno Schmidt; Travis C. Collier; Mark J. Hanemaaijer; Parker D. Houston; Yoosook Lee; Gregory C. Lanzaro

doi:10.1038/s41467-020-15204-0

Nature Communications (Mar 2020)

Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes

Hanno Schmidt,
Travis C. Collier,
Mark J. Hanemaaijer,
Parker D. Houston,
Yoosook Lee,
Gregory C. Lanzaro

Affiliations

Hanno Schmidt: Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California
Travis C. Collier: Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California
Mark J. Hanemaaijer: Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California
Parker D. Houston: Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California
Yoosook Lee: Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California
Gregory C. Lanzaro: Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California

DOI: https://doi.org/10.1038/s41467-020-15204-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 6

Abstract

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Genetic variation in natural populations could represent gene drive resistant alleles, preventing successful application for population management. Here the authors survey 1280 genomes from three mosquito species and concludes natural variation will not be detrimental to deploying gene drive technology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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