Protein and RNA dynamical fingerprinting

Katherine A. Niessen; Mengyang Xu; Deepu K. George; Michael C. Chen; Adrian R. Ferré-D’Amaré; Edward H. Snell; Vivian Cody; James Pace; Marius Schmidt; Andrea G. Markelz

doi:10.1038/s41467-019-08926-3

Nature Communications (Mar 2019)

Protein and RNA dynamical fingerprinting

Katherine A. Niessen,
Mengyang Xu,
Deepu K. George,
Michael C. Chen,
Adrian R. Ferré-D’Amaré,
Edward H. Snell,
Vivian Cody,
James Pace,
Marius Schmidt,
Andrea G. Markelz

Affiliations

Katherine A. Niessen: Department of Physics, University at Buffalo, SUNY
Mengyang Xu: Department of Physics, University at Buffalo, SUNY
Deepu K. George: Department of Physics, University at Buffalo, SUNY
Michael C. Chen: National Heart, Lung and Blood Institute
Adrian R. Ferré-D’Amaré: National Heart, Lung and Blood Institute
Edward H. Snell: Hauptman-Woodward Medical Research Institute & Department of Structural Biology, University at Buffalo, SUNY
Vivian Cody: Hauptman-Woodward Medical Research Institute & Department of Structural Biology, University at Buffalo, SUNY
James Pace: Hauptman-Woodward Medical Research Institute & Department of Structural Biology, University at Buffalo, SUNY
Marius Schmidt: Department of Physics, University of Wisconsin
Andrea G. Markelz: Department of Physics, University at Buffalo, SUNY

DOI: https://doi.org/10.1038/s41467-019-08926-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

The characterization of biomacromolecule structural vibrations has been impeded by a broad continuous vibrational density of states obscuring molecule specific vibrations. A terahertz microscopy system using polarization control produces signatures to dynamically fingerprint proteins and a RNA G-quadruplex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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