The World Journal of Men's Health (Jan 2022)
Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines
- Ashok Agarwal,
- Ala’a Farkouh,
- Neel Parekh,
- Armand Zini,
- Mohamed Arafa,
- Hussein Kandil,
- Nick Tadros,
- Gian Maria Busetto,
- Rafael Ambar,
- Sijo Parekattil,
- Florence Boitrelle,
- Hassan Sallam,
- Sunil Jindal,
- Edmund Ko,
- Mara Simopoulou,
- Hyun Jun Park,
- Mohammad Ali Sadighi,
- Ramadan Saleh,
- Jonathan Ramsay,
- Marlon Martine,
- Haitham Elbardisi,
- Juan Alvarez,
- Giovanni Colpi,
- Jaime Gosalvez,
- Donald Evenson,
- Rupin Shah
Affiliations
- Ashok Agarwal
- ORCiD
- American Center for Reproductive Medicine, Cleveland Clinic
- Ala’a Farkouh
- ORCiD
- American Center for Reproductive Medicine, Cleveland Clinic
- Neel Parekh
- ORCiD
- Department of Urology, Cleveland Clinic
- Armand Zini
- ORCiD
- Department of Surgery, McGill University, Montreal, QC, Canada
- Mohamed Arafa
- ORCiD
- American Center for Reproductive Medicine, Cleveland Clinic
- Hussein Kandil
- ORCiD
- Fakih IVF Fertility Center, Abu Dhabi, UAE
- Nick Tadros
- ORCiD
- Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA
- Gian Maria Busetto
- ORCiD
- Department of Urology and Renal Transplantation, University of Foggia, Policlinico Riuniti, Foggia, Italy
- Rafael Ambar
- ORCiD
- Department of Urology, Centro Universitario em Saude do ABC, Santo André, Brazil
- Sijo Parekattil
- ORCiD
- Avant Concierge Urology & University of Central Florida, Winter Garden, FL
- Florence Boitrelle
- ORCiD
- Biologie de la Reproduction - Preservation de la fertilite’ - Andrologie - CECOS CHI de Poissy Saint Germain en Laye Universite’ Paris, Saclay, France
- Hassan Sallam
- ORCiD
- Department of Obstetrics and Gynaecology, Alexandria University Faculty of Medicine, Alexandria, Egypt
- Sunil Jindal
- ORCiD
- Department of Andrology and Reproductive Medicine, Jindal Hospital, Meerut, India
- Edmund Ko
- ORCiD
- Department of Urology, Loma Linda University Health, Loma Linda, CA, USA
- Mara Simopoulou
- ORCiD
- Department of Experimental Physiology, School of Health Sciences, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece
- Hyun Jun Park
- ORCiD
- Department of Urology, Pusan National University School of Medicine
- Mohammad Ali Sadighi
- ORCiD
- Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
- Ramadan Saleh
- ORCiD
- Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt
- Jonathan Ramsay
- ORCiD
- Department of Andrology, Hammersmith Hospital, London, UK
- Marlon Martine
- ORCiD
- Section of Urology, University of Santo Tomas Hospital, Manila, Philippines
- Haitham Elbardisi
- ORCiD
- Department of Urology, Hamad Medical Corporation, Doha, Qatar
- Juan Alvarez
- ORCiD
- Centro Androgen, La Coruña, Spain and Harvard Medical School, Boston, MA, USA
- Giovanni Colpi
- ORCiD
- Andrology and IVF Unit, Procrea Institute, Lugano, Switzerland
- Jaime Gosalvez
- ORCiD
- Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain
- Donald Evenson
- ORCiD
- SCSA Diagnostics, Brookings, SD, USA
- Rupin Shah
- ORCiD
- Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India
- DOI
- https://doi.org/10.5534/wjmh.210056
- Journal volume & issue
-
Vol. 40,
no. 1
pp. 30 – 37
Abstract
Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid clinicians in the application of SDF for male fertility evaluation. Two recent clinical practice guidelines were published by Agarwal et al and Esteves et al. In this article, we have evaluated and compared both guidelines. We have found fairly similar recommendations between the two guidelines and have also highlighted the differences between them. Finally, we have summarized and combined the best practice recommendations from both guidelines.
Keywords
- dna fragmentation
- male infertility
- oxidative stress
- practice guidelines as topic
- assisted reproductive techniques
