Estimating prevalence of early symptomatic Alzheimer's disease in the United States

Abstract

Abstract INTRODUCTION Understanding the prevalence of treatment‐eligible Alzheimer's disease (AD) is crucial for policy planning. METHODS We used a comprehensive literature review and population cascade approach to estimate the number of amyloid‐positive, clinically diagnosed patients with mild cognitive impairment (MCI) or mild dementia due to AD in the United States. RESULTS An estimated 666,646 individuals were identified as having MCI due to AD (range: 351,926–1,227,776) and 620,850 individuals as having mild dementia due to AD (range: 445,082–820,339). In a US population of 76 million individuals aged 60 or older in 2021, the estimates of MCI and mild dementia due to AD increased with age. CONCLUSIONS As earlier diagnosis of AD and new disease‐modifying treatments become available, accurate population estimates are required to reduce uncertainty in the number of clinically diagnosed patients eligible for amyloid‐targeting therapies.

Keywords

• Alzheimer's disease
• dementia
• mild cognitive impairment
• population cascade
• population estimates