Epidemiology of adult patients with atopic dermatitis in AWARE 1: A second international survey

Jorge Maspero, MD; Norma De Paula Motta Rubini, MD; Jianzhong Zhang, MD; Gloria Sanclemente, MD; Julio Roberto Amador, MD; Mahira Hamdy El Sayed, MD; Alson Chan Wai Ming, MD; Roni P. Dodiuk-Gad, MD; Issam Hamadah, MD; Suganthi Thevarajah, MD; Catalina Rincón-Perez, MD; Elena Fedenko, MD; Yik Weng Yew, MD; Mark B.Y. Tang, MD; Chia-Yu Chu, MD, PhD; Kanokvalai Kulthanan, MD; Ozlem Su Kucuk, MD; Anwar Al-Hammadi, MD; Lysel Brignoli, MS; Angelina Tsankova, MBA; Sarah El-Samad, MD; Jose Eduardo Neves, MD; Laurent Eckert, MD

World Allergy Organization Journal (Mar 2023)

Epidemiology of adult patients with atopic dermatitis in AWARE 1: A second international survey

Jorge Maspero, MD,
Norma De Paula Motta Rubini, MD,
Jianzhong Zhang, MD,
Gloria Sanclemente, MD,
Julio Roberto Amador, MD,
Mahira Hamdy El Sayed, MD,
Alson Chan Wai Ming, MD,
Roni P. Dodiuk-Gad, MD,
Issam Hamadah, MD,
Suganthi Thevarajah, MD,
Catalina Rincón-Perez, MD,
Elena Fedenko, MD,
Yik Weng Yew, MD,
Mark B.Y. Tang, MD,
Chia-Yu Chu, MD, PhD,
Kanokvalai Kulthanan, MD,
Ozlem Su Kucuk, MD,
Anwar Al-Hammadi, MD,
Lysel Brignoli, MS,
Angelina Tsankova, MBA,
Sarah El-Samad, MD,
Jose Eduardo Neves, MD,
Laurent Eckert, MD

Affiliations

Jorge Maspero, MD: Fundación CIDEA (Centro de Investigación de Enfermedades Alérgicas y Respiratorias), University of Buenos Aires, Buenos Aires, Argentina; Corresponding author. Paraguay 2035 3° Cuerpo 2° Subsuelo, (C1121ABE) Ciudad de Buenos Aires, Buenos Aires, Argentina.
Norma De Paula Motta Rubini, MD: Department of Allergy & Immunology, Federal University of Rio de Janeiro (UNIRIO), Brazil
Jianzhong Zhang, MD: Department of Dermatology, Peking University People's Hospital, Beijing, China
Gloria Sanclemente, MD: Group of Investigative Dermatology (GRID), Institute of Medical Research, School of Medicine – University of Antioquia Medellin, Colombia
Julio Roberto Amador, MD: Hospital Militar Central and Universidad Militar Nueva Granada, Bogota, Colombia
Mahira Hamdy El Sayed, MD: Department of Dermatology and Venereology, Ain Shams University, Cairo, Egypt
Alson Chan Wai Ming, MD: Hong Kong Sanatorium and Hospital, Hong Kong, China
Roni P. Dodiuk-Gad, MD: Dermatology Department, Emek Medical Center, Afula, Israel
Issam Hamadah, MD: King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia
Suganthi Thevarajah, MD: Department of Dermatology, Hospital Kuala Lumpur, Malaysia
Catalina Rincón-Perez, MD: Ministry of National Defense, Medical Specialties Unit, State of Mexico, Mexico
Elena Fedenko, MD: National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, Russia
Yik Weng Yew, MD: National Skin Centre, Singapore
Mark B.Y. Tang, MD: Mount Alvernia Hospital, Singapore
Chia-Yu Chu, MD, PhD: Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Kanokvalai Kulthanan, MD: Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand
Ozlem Su Kucuk, MD: Department of Dermatology, School of Medicine, Bezmialem Vakif University, Istanbul, Turkey
Anwar Al-Hammadi, MD: Department of Dermatology, Dubai Medical Center, Dubai, United Arab Emirates
Lysel Brignoli, MS: Kantar Health, Paris, France
Angelina Tsankova, MBA: Kantar Health, Paris, France
Sarah El-Samad, MD: Sanofi, Dubai, United Arab Emirates
Jose Eduardo Neves, MD: Sanofi, Cambridge, MA, USA
Laurent Eckert, MD: Sanofi, Chilly-Mazarin, France

Journal volume & issue: Vol. 16, no. 3
p. 100724

Abstract

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Background: There are gaps in our understanding of the epidemiology of atopic dermatitis (AD) in adults. Objective: To evaluate the prevalence and severity of AD in adults from countries/regions within Asia, Eurasia, Latin America, Middle East, and Russia. Methods: This international, web-based survey was performed in Argentina, Brazil, China, Colombia, Egypt, Hong Kong, Israel, Malaysia, Mexico, Russia, Kingdom of Saudi Arabia (KSA), Singapore, Taiwan, Thailand, Turkey, and United Arab Emirates. Questionnaires were sent to adult members of online respondent panels for determination of AD and assessment of severity. A diagnosis of AD required respondents to meet the modified United Kingdom (UK) Working Party criteria and to self-report they had a physician diagnosis of AD. Severity of AD was determined using Patient-Oriented Scoring of Atopic Dermatitis (PO-SCORAD), Patient-Oriented Eczema Measure (POEM), and Patient Global Assessment (PGA). Results: Among respondents by country/region the prevalence of AD ranged from 3.4% in Israel to 33.7% in Thailand. The prevalence was generally higher in females versus males. Severity varied by scale, although regardless of scale the proportion of respondents with mild and moderate disease was higher than severe disease. PGA consistently resulted in the lowest proportion of severe AD (range 2.4% China – 10.8% Turkey) relative to PO-SCORAD (range 13.4% China – 41.6% KSA) and POEM (range 5.1% China – 16.6% Israel). Conclusions: This survey highlights the importance of AD in adults, with high prevalence and high morbidity among respondents and emphasizes that AD is not just a disease of childhood—there is disease persistence and chronicity in adults.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

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