Evaluation of Salivary Cardiac Troponin-I as Potential Marker for Detection of Acute Myocardial Infarction

Abstract

Introduction: Serum cardiac troponin-I is a specific biomarker and raised significantly after Myocardial Infarction. Saliva is a non-interventional bio-fluid which contains portion of serum constituents and can be key in diagnosis of MI. Aim: To estimate and correlate the level of cardiac Troponin-I (cTnI) in un-stimulated whole saliva and serum in acute MI patients and control group. Materials and Methods: Total of 60 individuals were enrolled and equally divided in to study (group I) and control group (Group II). Informed consent form was taken from all the subjects. Saliva and blood samples were obtained from patients with ECG features suggestive of acute MI within 24 hours. Serum and saliva samples were processed further for cTnI. The results obtained were then statistically analysed. Results: The mean cTnI level in serum of group I and group II were found to be 4.27±1.79 mg/L and 0.158±0.05 mg/L respectively. The mean cTnI level in saliva of group I and group II was found to be 0.67±0.10ng/L and 0.160±0.05 ng/L respectively. On analysing serum values and saliva values, p-value was found to be significant’. Conclusion: The saliva levels of cTnI were directly associated with serum levels demonstrating a highly significant strong positive relation and confirms the diagnostic ability of saliva for detection of cTnI.

Keywords

• cross-sectional studies
• diagnostic biomarkers
• heart muscle
• necrosis