Current state and perspectives of biotechnological production of antibiotics

Abstract

In this review, current state and development at trends in antibiotic biotechnology have been analyzed. Reasons prompting the search of novel and improvement of exis­ting antibiotics have been elucidated. Current strategies of investigations are discussed, particularly those that are aimed to increase the efficiency of screening of novel antibiotics, optimization of conditions of antibiotic biosynthesis as well as genetic and gene enginee­ring methods of construction of antibiotic producers. Data are presented on biotechnological production of antibiotics and their practical use in the world and Ukraine.

Keywords

• biotechnology
• antibiotics
• antibiotic resistance
• combinatorial biosynthesis