Proliferative vitreoretinopathy

Abstract

Background: Proliferative vitreoretinopathy (PVR) is a disease characterized by formation of membranes on both surfaces of the retina and vitreous base. PVR is a wound healing response which is inadequate and uncontrolled in the eye. Identifying the risk factors is important for PVR prediction. The distinction between anterior and posterior PVR is essential in predicting the surgery success.Conclusions: The anatomic and first of all functional success after vitrectomy are relatively poor. To improve the outcome the research has been focused on the use of pharmacological agents to prevent the development of PVR. A combination of 5-fluorouracil and low molecular weight heparin is the only proven effective therapy for PVR prevention.

Keywords

• proliferative vitreoretinopathy
• classification
• risk factors
• pharmacological therapy
• pars plana vitrectomy