Researching the activity of alkaline phosphatase of oral fluid in the treatment of patients with chronic generalized gingivitis

Abstract

Background. Gingivitis is an important medical and social problem that can have a significant impact on the human life quality. Treatment of gingivitis in most cases is carried out at the stage of chronic inflammation or its exacerbation. The reason for late seeking dental care for gingivitis is the lack of pronounced symptoms of the disease and patients' lack of awareness of possible risks. Alkaline phosphatase of oral fluid is considered to be one of the markers of the development of the inflammatory process in the oral cavity. Monitoring of its activity at the stages of treatment makes it possible to evaluate the effectiveness of therapy in patients with chronic gingival inflammation. The purpose of the study is to reserach the dynamics of alkaline phosphatase activity in the treatment of patients with chronic generalized gingivitis when using various forms of silver-containing drugs in a comprehensive treatment plan. Materials and methods. 3 groups of 25 patients from 21 to 36 years old with a diagnosis of chronic generalized gingivitis were formed. Patients received topical antimicrobial therapy twice a day for 10 days. Patients of the first group were applied with Vitargol, patients of the second group were applied Argogel, patients of the third group (comparison group) were prescribed rinses with 0.05% solution of chlorhexidine bigluconate. Results. 6 months after treatment, the activity of alkaline phosphatase decreased by 28.1% compared to baseline values in the first group, by 31.9% in the second group, and by 44.7% in the third group. Conclusions. Silver-containing drugs can serve as a worthy alternative if there are restrictions on the use of antibacterial drugs in patients with chronic generalized gingivitis.

Keywords

• chronic gingivitis
• alkaline phosphatase
• silver-containing drugs