Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus

Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Kenichi Ishii; Jyunichiro Yasukawa; Jie Su; Atsushi Miyashita; Hiroaki Itoh; Kotaro Tokumoto; Masayuki Inoue; Kazuhisa Sekimizu

doi:10.1038/s41467-021-26702-0

Nature Communications (Nov 2021)

Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus

Hiroshi Hamamoto,
Suresh Panthee,
Atmika Paudel,
Kenichi Ishii,
Jyunichiro Yasukawa,
Jie Su,
Atsushi Miyashita,
Hiroaki Itoh,
Kotaro Tokumoto,
Masayuki Inoue,
Kazuhisa Sekimizu

Affiliations

Hiroshi Hamamoto: Teikyo University Institute of Medical Mycology
Suresh Panthee: Drug Discoveries by Silkworm Models, Faculty of Pharma-Science, Teikyo University
Atmika Paudel: International Institute for Zoonosis Control, Hokkaido University
Kenichi Ishii: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Jyunichiro Yasukawa: Department of Biochemistry, Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts
Jie Su: National Marine Environmental Monitoring Center
Atsushi Miyashita: Teikyo University Institute of Medical Mycology
Hiroaki Itoh: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Kotaro Tokumoto: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Masayuki Inoue: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Kazuhisa Sekimizu: Drug Discoveries by Silkworm Models, Faculty of Pharma-Science, Teikyo University

DOI: https://doi.org/10.1038/s41467-021-26702-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Lysocin E is a lipopeptide with antibiotic activity against methicillin-resistant Staphylococcus aureus. Here, the authors show that the antimicrobial activity of lysocin E is potentiated through interactions with host serum proteins (such as apolipoprotein A-I) and bacterial membrane components.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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