SREBP modulates the NADP+/NADPH cycle to control night sleep in Drosophila

Vittoria Mariano; Alexandros K. Kanellopoulos; Giuseppe Aiello; Adrian C. Lo; Eric Legius; Tilmann Achsel; Claudia Bagni

doi:10.1038/s41467-022-35577-8

Nature Communications (Feb 2023)

SREBP modulates the NADP+/NADPH cycle to control night sleep in Drosophila

Vittoria Mariano,
Alexandros K. Kanellopoulos,
Giuseppe Aiello,
Adrian C. Lo,
Eric Legius,
Tilmann Achsel,
Claudia Bagni

Affiliations

Vittoria Mariano: Department of Fundamental Neurosciences, University of Lausanne
Alexandros K. Kanellopoulos: Department of Fundamental Neurosciences, University of Lausanne
Giuseppe Aiello: Department of Fundamental Neurosciences, University of Lausanne
Adrian C. Lo: Department of Fundamental Neurosciences, University of Lausanne
Eric Legius: Department of Human Genetics, KU Leuven
Tilmann Achsel: Department of Fundamental Neurosciences, University of Lausanne
Claudia Bagni: Department of Fundamental Neurosciences, University of Lausanne

DOI: https://doi.org/10.1038/s41467-022-35577-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

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Mechanisms underlying sleep dysfunctions in neurodevelopmental disorders remain elusive. Here, authors use a fly model for the CYFIP haploinsufficiency to show that increased SREBP activity impairs the NADP+/NADPH homeostasis inducing sleep deficits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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