Global Pediatric Health (Feb 2022)

Proximal Tubule Dysfunction Secondary to Salicylate Intoxication

  • Zachary C. Taylor BS,
  • Vanessa G. Carroll MD,
  • Hinah G. Parker MD

DOI
https://doi.org/10.1177/2333794X211050800
Journal volume & issue
Vol. 9

Abstract

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Aspirin overdose is still a common cause of presentation to the emergency department and is commonly seen in the setting of one-time, accidental or intentional ingestion of large amounts of salicylate-containing compounds, though can occur with long-term ingestion of super-therapeutic doses of medications. Salicylate toxicity has a predictable progression from early respiratory alkalosis to late metabolic acidosis. We present the case of a 14-year-old girl who intentionally ingested a handful of Aspirin and despite appropriate therapy, developed transient proximal tubule dysfunction. This case highlights the need for a change in the short-term medical management of children presenting with salicylate toxicity.