Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

Kyung Ah Han; Jaewon Ko

doi:10.1038/s12276-023-01004-1

Experimental and Molecular Medicine (Jun 2023)

Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

Kyung Ah Han,
Jaewon Ko

Affiliations

Kyung Ah Han: Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun
Jaewon Ko: Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun

DOI: https://doi.org/10.1038/s12276-023-01004-1
Journal volume & issue: Vol. 55, no. 6
pp. 1065 – 1075

Abstract

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Abstract The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.

Published in Experimental and Molecular Medicine

ISSN: 1226-3613 (Print); 2092-6413 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.nature.com/emm/

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