Scientific Reports (Jun 2024)
Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis
- Inga Meyhoefer,
- Andreas Sprenger,
- David Derad,
- Dominik Grotegerd,
- Ramona Leenings,
- Elisabeth J. Leehr,
- Fabian Breuer,
- Marian Surmann,
- Karen Rolfes,
- Volker Arolt,
- Georg Romer,
- Markus Lappe,
- Johanna Rehder,
- Nikolaos Koutsouleris,
- Stefan Borgwardt,
- Frauke Schultze-Lutter,
- Eva Meisenzahl,
- Tilo T. J. Kircher,
- Sarah S. Keedy,
- Jeffrey R. Bishop,
- Elena I. Ivleva,
- Jennifer E. McDowell,
- James L. Reilly,
- Scot Kristian Hill,
- Godfrey D. Pearlson,
- Carol A. Tamminga,
- Matcheri S. Keshavan,
- Elliot S. Gershon,
- Brett A. Clementz,
- John A. Sweeney,
- Tim Hahn,
- Udo Dannlowski,
- Rebekka Lencer
Affiliations
- Inga Meyhoefer
- Institute for Translational Psychiatry, University of Muenster
- Andreas Sprenger
- Department of Neurology, University of Luebeck
- David Derad
- Department of Neurology, University of Luebeck
- Dominik Grotegerd
- Institute for Translational Psychiatry, University of Muenster
- Ramona Leenings
- Institute for Translational Psychiatry, University of Muenster
- Elisabeth J. Leehr
- Institute for Translational Psychiatry, University of Muenster
- Fabian Breuer
- Institute for Translational Psychiatry, University of Muenster
- Marian Surmann
- Institute for Translational Psychiatry, University of Muenster
- Karen Rolfes
- Institute for Translational Psychiatry, University of Muenster
- Volker Arolt
- Institute for Translational Psychiatry, University of Muenster
- Georg Romer
- Department of Child Adolescence Psychiatry and Psychotherapy, University of Muenster
- Markus Lappe
- Otto-Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster
- Johanna Rehder
- Institute of Psychology, University of Muenster
- Nikolaos Koutsouleris
- Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University Munich
- Stefan Borgwardt
- Department of Psychiatry and Psychotherapy, University of Luebeck
- Frauke Schultze-Lutter
- Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Duesseldorf/LVR
- Eva Meisenzahl
- Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Duesseldorf/LVR
- Tilo T. J. Kircher
- Department of Psychiatry and Psychotherapy, Philipps-University Marburg
- Sarah S. Keedy
- Department of Psychiatry and Behavioral Neuroscience, University of Chicago
- Jeffrey R. Bishop
- Department of Experimental and Clinical Pharmacology and Department of Psychiatry and Behavioral Sciences, University of Minnesota
- Elena I. Ivleva
- Department of Psychiatry, The University of Texas Southwestern Medical Center
- Jennifer E. McDowell
- Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia
- James L. Reilly
- Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine
- Scot Kristian Hill
- Department of Psychology, Rosalind Franklin University of Medicine and Science
- Godfrey D. Pearlson
- Departments of Psychiatry and Neuroscience, Yale School of Medicine, and Olin Research Center, Institute of Living/Hartford Hospital
- Carol A. Tamminga
- Department of Psychiatry, The University of Texas Southwestern Medical Center
- Matcheri S. Keshavan
- Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center
- Elliot S. Gershon
- Department of Psychiatry and Behavioral Neuroscience, University of Chicago
- Brett A. Clementz
- Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia
- John A. Sweeney
- Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University
- Tim Hahn
- Institute for Translational Psychiatry, University of Muenster
- Udo Dannlowski
- Institute for Translational Psychiatry, University of Muenster
- Rebekka Lencer
- Institute for Translational Psychiatry, University of Muenster
- DOI
- https://doi.org/10.1038/s41598-024-64487-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
Abstract Smooth pursuit eye movements are considered a well-established and quantifiable biomarker of sensorimotor function in psychosis research. Identifying psychotic syndromes on an individual level based on neurobiological markers is limited by heterogeneity and requires comprehensive external validation to avoid overestimation of prediction models. Here, we studied quantifiable sensorimotor measures derived from smooth pursuit eye movements in a large sample of psychosis probands (N = 674) and healthy controls (N = 305) using multivariate pattern analysis. Balanced accuracies of 64% for the prediction of psychosis status are in line with recent results from other large heterogenous psychiatric samples. They are confirmed by external validation in independent large samples including probands with (1) psychosis (N = 727) versus healthy controls (N = 292), (2) psychotic (N = 49) and non-psychotic bipolar disorder (N = 36), and (3) non-psychotic affective disorders (N = 119) and psychosis (N = 51) yielding accuracies of 65%, 66% and 58%, respectively, albeit slightly different psychosis syndromes. Our findings make a significant contribution to the identification of biologically defined profiles of heterogeneous psychosis syndromes on an individual level underlining the impact of sensorimotor dysfunction in psychosis.
Keywords
