Immunophenotypic Modulation of the Blast Cells in Childhood Acute Lymphoblastic Leukemia Minimal Residual Disease Detection

Burnusuzov Hasan A.; Spasova Mariya I.; Murdjeva Mariana A.; Stoyanova Angelina A.; Mumdziev Ivan N.; Kaleva Valeriya I.; Belcheva Milena I.; Bosheva Miroslava N.

doi:10.1515/folmed-2016-0004

Folia Medica (Mar 2016)

Immunophenotypic Modulation of the Blast Cells in Childhood Acute Lymphoblastic Leukemia Minimal Residual Disease Detection

Burnusuzov Hasan A.,
Spasova Mariya I.,
Murdjeva Mariana A.,
Stoyanova Angelina A.,
Mumdziev Ivan N.,
Kaleva Valeriya I.,
Belcheva Milena I.,
Bosheva Miroslava N.

Affiliations

Burnusuzov Hasan A.: Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, 15A Vasil Aprilov Blvd, 4002, Bulgaria
Spasova Mariya I.: Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria
Murdjeva Mariana A.: Department of Microbiology and Immunology, Medical University of Plovdiv, Plovdiv, Bulgaria
Stoyanova Angelina A.: Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria
Mumdziev Ivan N.: Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria
Kaleva Valeriya I.: Department of Pediatrics and Medical Genetics, Medical University of Varna, Varna, Bulgaria
Belcheva Milena I.: Department of Pediatrics and Medical Genetics, Medical University of Varna, Varna, Bulgaria
Bosheva Miroslava N.: Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria

DOI: https://doi.org/10.1515/folmed-2016-0004
Journal volume & issue: Vol. 58, no. 1
pp. 28 – 35

Abstract

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Early clearance of leukemic cells during induction therapy of childhood acute lymphoblastic leukemia (ALL) is a basis for treatment optimization. Currently, the most widely used methods for the detection of minute residual malignant cells in the bone marrow and/or peripheral blood, minimal residual disease (MRD), are PCR and flow cytometry (FCM). Immunophenotypic modulation (IM) is a well known factor that can hamper the accurate FCM analysis.

Published in Folia Medica

ISSN: 0204-8043 (Print); 1314-2143 (Online)
Publisher: Pensoft Publishers
Country of publisher: Bulgaria
LCC subjects: Medicine
Website: https://foliamedica.bg

About the journal

Abstract

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