Biologically Active Terpenoids Ligularia Macrophylla (Ledeb.) DC. аnd Technology of New Drug Substance

Abstract

The article presents the results of a chemical study of Ligularia macrophylla (Ledeb.) DC. The essential oil was isolated by hydrodistillation using a Clevenger apparatus and microwave extraction using a NEOS installation. Using mass spectrometry, 52 components were identified in the essential oil isolated by hydrodistillation; 63 components were identified in the essential oil isolated by microwave extraction. The main components of the essential oil are Δ3-carene, β-bisabolene, β-myrcene. It was revealed that the substance obtained from the essential oil of Ligularia macrophylla (Ledeb.) DC. has anti-inflammatory and antimicrobial activity. For the first time, the optimal technological parameters for alcohol extraction of Ligularia macrophylla (Ledeb.) DC roots were determined using the method of mathematical modeling, providing a quantitative yield of the sesquiterpene lactone furanoeremophilan-14β,6α-olide, which has anti-inflammatory activity.

Keywords

• Ligularia macrophylla (Ledeb.) DC
• extraction
• hydrodistillation
• microwave extraction
• essential oil
• furanoeremophilan-14β,6α-olide