A critical role for NF2 and the Hippo pathway in branching morphogenesis

Antoine Reginensi; Leonie Enderle; Alex Gregorieff; Randy L. Johnson; Jeffrey L. Wrana; Helen McNeill

doi:10.1038/ncomms12309

Nature Communications (Aug 2016)

A critical role for NF2 and the Hippo pathway in branching morphogenesis

Antoine Reginensi,
Leonie Enderle,
Alex Gregorieff,
Randy L. Johnson,
Jeffrey L. Wrana,
Helen McNeill

Affiliations

Antoine Reginensi: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Leonie Enderle: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Alex Gregorieff: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Randy L. Johnson: Department of Biochemistry & Molecular Biology, University of Texas MD Anderson Cancer Center
Jeffrey L. Wrana: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Helen McNeill: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital

DOI: https://doi.org/10.1038/ncomms12309
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

Branching morphogenesis is essential for the formation of most epithelial organs. Here, the authors show that Neurofibromatosis 2 (NF2), the Hippo pathway kinases LATS1 and LATS2, and the transcriptional co-activators YAP and TAZ control tip identity, RET signalling and branching morphogenesis in the mouse kidney.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal