Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

Jeffrey Y. W. Mak; Weijun Xu; Robert C. Reid; Alexandra J. Corbett; Bronwyn S. Meehan; Huimeng Wang; Zhenjun Chen; Jamie Rossjohn; James McCluskey; Ligong Liu; David P. Fairlie

doi:10.1038/ncomms14599

Nature Communications (Mar 2017)

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

Jeffrey Y. W. Mak,
Weijun Xu,
Robert C. Reid,
Alexandra J. Corbett,
Bronwyn S. Meehan,
Huimeng Wang,
Zhenjun Chen,
Jamie Rossjohn,
James McCluskey,
Ligong Liu,
David P. Fairlie

Affiliations

Jeffrey Y. W. Mak: Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland
Weijun Xu: Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland
Robert C. Reid: Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland
Alexandra J. Corbett: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Bronwyn S. Meehan: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Huimeng Wang: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Zhenjun Chen: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Jamie Rossjohn: Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
James McCluskey: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Ligong Liu: Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland
David P. Fairlie: Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland

DOI: https://doi.org/10.1038/ncomms14599
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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