Journal of Veterinary Medical Research (Dec 2005)
Pharmacokinetics and bioavailability of difloxacin in camel
Abstract
The pharmacokinetic profile of difloxacin was investigated in camels after single intravenous and intramuscular administration of 5 mg kg-1 b.wt. After i. v. injection, serum concentration time curve was best described as two compartment open model. The distribution and elimination half lives (t0.5 (') and t0.5())) were 0.513± 0.01 h and 6.3±0.15 h. respectively. Difloxacin was distributed extravascularly with a volume of distribution (Vdss) 1.10 ± 0.035 l kg-1., and total body clearance (CLB) of 0.141+ 0.031 l kg-1 h-1. following intramusclar injection, peak serum concentration (Cmax) 2.59 ± 0.19 ug ml-1 attained after Tmax 3.05 ± 0.035 h. The absorption and elimination half lives (t0.5 (ab) and t0.5 (el)) were 0.95 ± 0.003 and 5.86 ± 0.33 h., respectively. The systemic bioavailablility (F) and the plasma protein binding were 87.95 and 23 %, respectively.